3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-(diphenylmethyl)azetidin-3-yl)-1H-1,2,3-triazol-4-yl)-2-aminopyridine → 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(azetidin-3-yl)-1H-1,2,3-triazol-4-yl)-2-aminopyridine

HRID 1845892ノート

反応式

HRID 1845892 の反応式
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[CH:10]([O:12][C:13]1[C:14]([NH2:41])=[N:15][CH:16]=[C:17]([C:19]2[N:20]=[N:21][N:22]([CH:24]3[CH2:27][N:26](C(C4C=CC=CC=4)C4C=CC=CC=4)[CH2:25]3)[CH:23]=2)[CH:18]=1)[CH3:11]>CO.[OH-].[OH-].[Pd+2]>[Cl:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[CH:10]([O:12][C:13]1[C:14]([NH2:41])=[N:15][CH:16]=[C:17]([C:19]2[N:20]=[N:21][N:22]([CH:24]3[CH2:25][NH:26][CH2:27]3)[CH:23]=2)[CH:18]=1)[CH3:11]

参加物

4

反応物 1

HCID 897084703-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-(diphenylmethyl)azetidin-3-yl)-1H-1,2,3-triazol-4-yl)-2-aminopyridine

生成物 1

HCID 897084743-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(azetidin-3-yl)-1H-1,2,3-triazol-4-yl)-2-aminopyridine

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

The product of the above mentioned Example 9 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(1-(diphenylmethyl)azetidin-3-yl)-1H-1,2,3-triazol-4-yl)-2-aminopyridine (2.2 g, 3.73 mmol) was dissolved in methanol (40 mL), and palladium hydroxide/carbon (220 mg) was added to perform the hydrogenation reaction. TLC test showed that the raw materials were completely reacted. After filtration, the filtrate was concentrated under reduced pressure to yield the target product as white solid powder.

後処理

  1. customthe hydrogenation reaction
  2. customwere completely reacted
  3. filtrationAfter filtration
  4. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-7b71a70d925c49998cc7943a045704c8
出典データセット
uspto-grants-2015_02
特許番号
US08952002B2

反応ノート

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