(S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine → (S)-3-(1-(2,6-Dichloro-3-fluorophenyl)-ethoxy)pyridin-2-amine

HRID 1845894ノート

反応式

HRID 1845894 の反応式
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[C@@H:10]([O:12][C:13]1[C:14]([N+:19]([O-])=O)=[N:15][CH:16]=[CH:17][CH:18]=1)[CH3:11]>C(O)C.[Pd]>[Cl:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[C@@H:10]([O:12][C:13]1[C:14]([NH2:19])=[N:15][CH:16]=[CH:17][CH:18]=1)[CH3:11]

参加物

4

反応物 1

HCID 86327669(S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

生成物 1

HCID 86327671(S)-3-(1-(2,6-Dichloro-3-fluorophenyl)-ethoxy)pyridin-2-amine収率 87%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The compound (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine (15.2 g, 45.9 mmol) was suspended in ethanol (150 mL), and palladium/carbon was added to perform the hydrogenation reaction. TLC test showed that the raw materials were completely reacted. The reaction liquid was filtered; the filtrate was concentrated under reduced pressure to remove ethanol to yield (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-aminopyridine (12 g, yield: 87%).

後処理

  1. customthe hydrogenation reaction
  2. customwere completely reacted
  3. customThe reaction liquid
  4. filtrationwas filtered
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. customto remove ethanol

出典と根拠

ORDレコード
ord-5fe28263153a4bbc992eb0b5e618e4d9
出典データセット
uspto-grants-2015_02
特許番号
US08952002B2

反応ノート

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