Trifluoroacetic acid → 6-Amino-4-methyl-1,3-benzoxazol-2(3H)-one

HRID 1846427ノート

反応式

HRID 1846427 の反応式
C(O)(C(F)(F)F)=O.[CH3:8][C:9]1[C:14]2[NH:15][C:16](=[O:18])[O:17][C:13]=2[CH:12]=[C:11]([NH:19]C(=O)OC(C)(C)C)[CH:10]=1>C(Cl)Cl>[NH2:19][C:11]1[CH:10]=[C:9]([CH3:8])[C:14]2[NH:15][C:16](=[O:18])[O:17][C:13]=2[CH:12]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67126852Tert-butyl (4-methyl-2-oxo-2,3-dihydro-benzoxazol-6-yl)-carbamate

生成物 1

HCID 199116046-Amino-4-methyl-1,3-benzoxazol-2(3H)-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

400 μL (5.30 mmol) TFA were added to 230 mg (0.900 mmol) tert-butyl (4-methyl-2-oxo-2,3-dihydro-benzoxazol-6-yl)-carbamate in 5.0 ml DCM and the mixture was stirred for 1.5 h at RT. The reaction mixture was evaporated down and the residue was divided between semisaturated sodium hydrogen carbonate solution and EtOAc. The organic phase was dried on sodium sulphate, filtered and evaporated down.

後処理

  1. customThe reaction mixture was evaporated down
  2. customThe organic phase was dried on sodium sulphate
  3. filtrationfiltered
  4. customevaporated down

出典と根拠

ORDレコード
ord-baf8ec1fae1d465cbd77798864253e97
出典データセット
uspto-grants-2015_02
特許番号
US08952014B2

反応ノート

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