4-Amino-3-methyl-5-nitrophenol → 3,4-Diamino-5-methylphenol

HRID 1846488ノート

反応式

HRID 1846488 の反応式
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([OH:11])=[CH:4][C:3]=1[CH3:12].[H][H]>CO.[Pd]>[NH2:8][C:7]1[CH:6]=[C:5]([OH:11])[CH:4]=[C:3]([CH3:12])[C:2]=1[NH2:1]

参加物

5

反応物 2

HCID 669782964-Amino-3-methyl-5-nitrophenolHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 199076443,4-Diamino-5-methylphenol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

2.00 g (11.06 mmol) 4-amino-3-methyl-5-nitrophenol were placed in 50 mL methanol and hydrogenated under a hydrogen atmosphere and with the addition of 1.00 g Pd/C (10%) at 50° C. and a hydrogen pressure of 5 bar until all the hydrogen had been taken up. The catalyst was filtered off and the filtrate was evaporated down i.vac.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated down i.vac

出典と根拠

ORDレコード
ord-df0ec7a994e64585a5891541074e1775
出典データセット
uspto-grants-2015_02
特許番号
US08952014B2

反応ノート

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