Diisopropylethylamine → N-(2-chloro-4-hydroxy-6-nitrophenyl)tetrahydrofuran-3-carboxamide

HRID 1846490

反応式

HRID 1846490 の反応式
[NH2:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([OH:11])=[CH:4][C:3]=1[Cl:12].CCN(C(C)C)C(C)C.[O:22]1[CH2:26][CH2:25][CH:24]([C:27](Cl)=[O:28])[CH2:23]1>C(Cl)Cl>[Cl:12][C:3]1[CH:4]=[C:5]([OH:11])[CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]=1[NH:1][C:27]([CH:24]1[CH2:25][CH2:26][O:22][CH2:23]1)=[O:28]

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 14020412Tetrahydrofuran-3-carbonyl chloride2 回HCID 669783384-Amino-3-chloro-5-nitrophenol

生成物 1

HCID 66978219N-(2-chloro-4-hydroxy-6-nitrophenyl)tetrahydrofuran-3-carboxamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

0.40 g (2.12 mmol) 4-amino-3-chloro-5-nitrophenol were placed in 5 mL DCM. 0.44 mL DIPEA and 0.34 g tetrahydrofuran-3-carbonyl chloride were added and the mixture was stirred for 2 h at RT. A further 0.34 g tetrahydrofuran-3-carbonyl chloride was added and the mixture was stirred overnight at RT. The reaction mixture was diluted with DCM and washed with water. The organic phase was evaporated down i.vac.

後処理

  1. stirringthe mixture was stirred overnight at RT
  2. washwashed with water
  3. customThe organic phase was evaporated down i.vac

出典と根拠

ORDレコード
ord-750612a2b2be49fea853381032bdd2ab
出典データセット
uspto-grants-2015_02
特許番号
US08952014B2

関連ノート

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