Diisopropylethylamine → HCID 46244510、化合物

HRID 1846535ノート

反応式

HRID 1846535 の反応式
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[N:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:16])[CH2:3][CH2:2]1.Cl[C:18]1[N:23]=[C:22]([CH3:24])[N:21]=[C:20]([O:25][C:26]2[CH:35]=[C:34]([CH3:36])[C:29]3[NH:30][C:31](=[O:33])[O:32][C:28]=3[CH:27]=2)[CH:19]=1.CCN(C(C)C)C(C)C>CN(C=O)C.O>[CH3:24][C:22]1[N:23]=[C:18]([N:1]2[CH2:2][CH2:3][CH:4]([N:7]3[C:15]4[C:10](=[N:11][CH:12]=[CH:13][CH:14]=4)[NH:9][C:8]3=[O:16])[CH2:5][CH2:6]2)[CH:19]=[C:20]([O:25][C:26]2[CH:35]=[C:34]([CH3:36])[C:29]3[NH:30][C:31](=[O:33])[O:32][C:28]=3[CH:27]=2)[N:21]=1

参加物

6

反応物 3

HCID 81531DiisopropylethylamineHCID 22293182Bms-9730132 回HCID 86663906HCID 86663906、化合物

生成物 1

HCID 46244510HCID 46244510、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

38 mg (0.17 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one, 50 mg (0.17 mmol) 6-(6-chloro-2-methyl-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one and 0.10 mL (0.57 mmol) DIPEA were combined in 1.8 mL DMF and stirred overnight at 80° C. Then another 15 mg (0.069 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one were added and the mixture was further stirred overnight at RT. The reaction mixture was diluted with water, the precipitate formed was suction filtered and dried i. vac.

後処理

  1. waitthe mixture was further stirred overnight at RT
  2. customthe precipitate formed
  3. filtrationfiltered
  4. customdried i

出典と根拠

ORDレコード
ord-b42dd261e10843c9a852d933f65b7ec2
出典データセット
uspto-grants-2015_02
特許番号
US08952014B2

反応ノート

読み込み中…