Acetonitrile → HCID 53307908、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][CH:24]=1)[C:5]([NH:7][C:8]1[C:9]([N:15]2[CH2:21][CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[N:10][CH:11]=[C:12]([Cl:14])[CH:13]=1)=[O:6].[C:25](#[N:27])[CH3:26]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][CH:24]=1)[C:5]([NH:7][C:8]1[C:9]([N:15]2[CH2:21][CH2:20][CH2:19][N:18]([CH2:26][CH2:25][N:27]3[CH2:4][CH2:3][CH2:2][CH2:24][CH2:23]3)[CH2:17][CH2:16]2)=[N:10][CH:11]=[C:12]([Cl:14])[CH:13]=1)=[O:6]参加物
3
反応条件
- 温度
- 175 °C
実験手順
A mixture of 0.035 g (0.096 mmol) of 3-chloro-N-(5-chloro-2-[1,4]diazepan-1-yl-pyridin-3-yl)-benzamide in 0.053 g (0.29 mmol) of 2-pyridino-1-ethylchloride hydrochloride in acetonitrile (2 mL) is heated at 175° C. in a microwave reactor for 30 minutes. The mixture is cooled to room temperature and concentrated under reduced pressure. The residue is purified by flash silica gel chromatography to provide 0.004 g (9%) of the title compound (108) as a red solid. [M+H]+=476.2.
後処理
- temperatureThe mixture is cooled to room temperature
- concentration