3-Benzyloxycyclobutane-1,1-dicarboxylic acid → 3-(Benzyloxy)cyclobutane-1-carboxylic acid

HRID 1846753ノート

反応式

HRID 1846753 の反応式
[CH2:1]([O:8][CH:9]1[CH2:12][C:11](C(O)=O)([C:13]([OH:15])=[O:14])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>N1C=CC=CC=1>[CH2:1]([O:8][CH:9]1[CH2:10][CH:11]([C:13]([OH:15])=[O:14])[CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 1

HCID 6387653-Benzyloxycyclobutane-1,1-dicarboxylic acid

生成物 1

HCID 128151113-(Benzyloxy)cyclobutane-1-carboxylic acid収率 95%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid (1.5 g, 5.99 mmol) in pyridine (3 mL) was heated in a 120° C. oil bath for 12 h. The mixture was cooled to RT and the pyridine was removed under vacuum. Toluene (10 mL) was added and the solution was washed with 1N HCl (3×), dried (MgSO4), filtered, and concentrated in vacuo to give product as a brown oil (1.17 g, 95%).

後処理

  1. customthe pyridine was removed under vacuum
  2. additionToluene (10 mL) was added
  3. washthe solution was washed with 1N HCl (3×)
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-161fb393cbd24dc28f77b7822cf23a18
出典データセット
uspto-grants-2015_02
特許番号
US08952037B2

反応ノート

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