HCID 178522112、化合物 → HCID 178522109、化合物

HRID 1846802ノート

反応式

HRID 1846802 の反応式
C([O:8][C@H:9]1[CH2:12][C@H:11]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[O:14])[CH2:10]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[OH:8][C@H:9]1[CH2:12][C@H:11]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[O:14])[CH2:10]1

参加物

4

反応物 1

HCID 178522112HCID 178522112、化合物

生成物 1

HCID 178522109HCID 178522109、化合物

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

trans-3-(benzyloxy)-N-(pyridin-2-yl)cyclobutanecarboxamide (0.394 g, 1.40 mmol) and palladium hydroxide (0.098 g, 0.14 mmol, 20 weight % on carbon) were mixed in ethanol (5 mL). The reaction mixture was placed under a hydrogen atmosphere (balloon) and stirred at 70° C. for 20 h. The reaction mixture was cooled to RT and filtered. The filtrate was concentrated, and the resulting crude product was purified via silica gel chromatography to give trans-3-hydroxy-N-(pyridin-2-yl)cyclobutanecarboxamide as an off white solid.

後処理

  1. temperatureThe reaction mixture was cooled to RT
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated
  4. customthe resulting crude product was purified via silica gel chromatography

出典と根拠

ORDレコード
ord-fad087c2c0884ee58f95d65885fa6bd6
出典データセット
uspto-grants-2015_02
特許番号
US08952037B2

反応ノート

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