Hydrochloric Acid → 3-(7-Methoxy-2-oxoquinoxalin-1(2H)-yl)propanal

HRID 1846997ノート

反応式

HRID 1846997 の反応式
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[N:9]=[CH:8][C:7]1=[O:18].Cl>O1CCCC1.ClCCl>[CH3:17][O:16][C:13]1[CH:14]=[C:15]2[C:10]([N:9]=[CH:8][C:7](=[O:18])[N:6]2[CH2:5][CH2:4][CH:3]=[O:2])=[CH:11][CH:12]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 867249271-(3,3-Dimethoxypropyl)-7-methoxyquinoxalin-2(1H)-one

生成物 1

HCID 867249283-(7-Methoxy-2-oxoquinoxalin-1(2H)-yl)propanal収率 94.1%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

1-(3,3-Dimethoxypropyl)-7-methoxyquinoxalin-2(1H)-one (300 mg, 1.08 mmol) was dissolved in tetrahydrofuran (3 ml). 1N Hydrochloric acid (3 ml) was added to this solution and the mixture was stirred at room temperature for 3.5 hours. The reaction solution was diluted with dichloromethane and stirred, and the organic layer was then separated. The organic layer was washed with saturated sodium chloride solution, dried over magnesium sulfate and then the solvent was removed under reduced pressure to yield 236 mg (94%) of the title compound in the form of a light brown solid.

後処理

  1. stirringstirred
  2. customthe organic layer was then separated
  3. washThe organic layer was washed with saturated sodium chloride solution
  4. dry with materialdried over magnesium sulfate
  5. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-5af76eacfffa47a8bb64741ab3074d97
出典データセット
uspto-grants-2015_02
特許番号
US08952010B2

反応ノート

読み込み中…