反応式
[O:1]1CCO[CH:2]1[CH2:6][CH2:7][N:8]1[C:13]2=[N:14][C:15]([O:18][CH3:19])=[CH:16][N:17]=[C:12]2[CH:11]=[CH:10][C:9]1=[O:20].Cl>O1CCCC1>[CH3:19][O:18][C:15]1[N:14]=[C:13]2[N:8]([CH2:7][CH2:6][CH:2]=[O:1])[C:9](=[O:20])[CH:10]=[CH:11][C:12]2=[N:17][CH:16]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
5-[2-(1,3-Dioxolan-2-yl)ethyl]-3-methoxypyrido[2,3-b]pyrazin-6(5H)-one (397 mg, 1.43 mmol) was dissolved in tetrahydrofuran (15 ml). To the solution was added a 1N hydrochloric acid aqueous solution (5 ml) under cooling on ice and the mixture was stirred at room temperature for two and a half hours and at 50° C. for 4 hours. After cooling in the air, the solvent was removed under reduced pressure and the residue was alkalized by adding saturated sodium bicarbonate water under cooling on ice. The resultant was extracted with dichloromethane, the extract was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure to yield 292 mg (87%) of the title compound in the form of a yellowish solid.
後処理
- temperatureunder cooling on ice
- temperatureAfter cooling in the air
- customthe solvent was removed under reduced pressure
- additionby adding saturated sodium bicarbonate water
- temperatureunder cooling on ice
- extractionThe resultant was extracted with dichloromethane
- dry with materialthe extract was dried over anhydrous sodium sulfate
- customthe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-34d59c866ecf441c82864c3c65890d83
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08952010B2
関連ノート
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