Methanol → HCID 68154716、化合物

HRID 1847612ノート

反応式

HRID 1847612 の反応式
[O:1]=[C:2]1[N:7]([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)[CH:6]=[C:5]([C:13]([O:15]C)=[O:14])[CH:4]=[CH:3]1.[OH-].[Li+].[CH3:19]O>O>[CH3:19][C:6]1[N:7]([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)[C:2](=[O:1])[CH:3]=[CH:4][C:5]=1[C:13]([OH:15])=[O:14]

参加物

5

反応物 3

HCID 887MethanolHCID 3939Lithium HydroxideHCID 14920282HCID 14920282、化合物

生成物 1

HCID 68154716HCID 68154716、化合物収率 73%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
75 °C

実験手順

After 680 mg (2.88 mmol) of methyl 6-oxo-1-(2-thiazolyl)-1,6-dihydro-3-pyridinecarboxylate was dissolved in 12 mL of methanol and 4 mL of water, 207 mg (8.64 mmol) of lithium hydroxide was added to the solution. Afterward, the resulting reaction solution was stirred at about 75° C. for 5 hours. After termination of the reaction was determined by liquid chromatography, the solvent was removed in vacuo, and aqueous HCl was then added to the reaction solution to titrate until pH 2 was reached. The resulting solid compound was filtrated to obtain a target compound (Actual yield: 466 mg, Percent yield: 73%).

後処理

  1. customAfterward, the resulting reaction solution
  2. customthe solvent was removed in vacuo, and aqueous HCl
  3. additionwas then added to the reaction solution
  4. filtrationThe resulting solid compound was filtrated
  5. customto obtain a target compound (Actual yield: 466 mg, Percent yield: 73%)

出典と根拠

ORDレコード
ord-13ba772f8c3443dfb5f942aa2224c337
出典データセット
uspto-grants-2015_02
特許番号
US08952165B2

反応ノート

読み込み中…