Ammonia → HCID 53825865、化合物

反応式

ClCCl.[NH3:4].[C:5]([C:8]1[CH:15]=[CH:14][C:11]([CH2:12]Cl)=[C:10]([CH3:16])[CH:9]=1)(=[O:7])[CH3:6].[O:17]1CCCC1>>[C:5]([C:8]1[CH:15]=[CH:14][C:11]([C:12]([NH2:4])=[O:17])=[C:10]([CH3:16])[CH:9]=1)(=[O:7])[CH3:6]

参加物

反応物 4

HCID 222Ammonia

HCID 6344Dichloromethane2 回

HCID 8028Tetrahydrofuran

HCID 68613712HCID 68613712、化合物

生成物 1

HCID 53825865HCID 53825865、化合物

実験手順

21 ml of dichloromethane was added to 2 g of concentrated aqueous ammonia, and the mixture was cooled with ice. A dichloromethane (3 ml) solution of 1.39 g of crude 4-acetyl-2-methylbenzyl chloride was added slowly to the mixture, and stirred for 2 hours with ice cooling. 24 ml of tetrahydrofuran was added to the reaction solution, and further stirred for 2 hours at room temperature. Then, large part of the solvent was distilled off under reduced pressure, and the slurry-state reaction solution was filtered. The obtained solid was washed with water and toluene. The solid was dried under reduced pressure to obtain 1.03 g of 4-acetyl-2-methylbenzoic acid amide.