Hydrogen Bromide → 4-hydroxy-3-isopropylfuran-2(5H)-one
反応式
BrC[C:3](=[O:13])[CH:4]([CH:10]([CH3:12])[CH3:11])[C:5]([O:7][CH2:8]C)=[O:6].Br>>[OH:13][C:3]1[CH2:8][O:7][C:5](=[O:6])[C:4]=1[CH:10]([CH3:11])[CH3:12]参加物
3
反応条件
- 温度
- 100 °C
実験手順
A mixture of ethyl 4-bromo-2-isopropyl-3-oxobutanoate (7.1 g, 28 mmol) and hydrogen bromide (48%, 0.032 mL, 0.28 mmol) was heated at 100° C. for 8 h. After cooling to rt, the solid was collected by filtration followed by diethyl ether washing to give 4-hydroxy-3-isopropylfuran-2(5H)-one. LC/MS: (M+1)+: 143.09.
後処理
- temperatureAfter cooling to rt
- filtrationthe solid was collected by filtration
出典と根拠
- ORDレコード
- ord-8840b3c7e86745c68fdef7c57c601ecf
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08952166B2
反応ノート
読み込み中…