HCID 86709483、化合物 → HCID 86709484、化合物
反応式
[CH3:1][N:2]1[CH2:9][C@H:8]2[N:10]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[C@H:4]([CH2:5][C:6]([C:18]([O:20][CH3:21])=[O:19])=[CH:7]2)[CH2:3]1>CO.[Pd]>[CH3:1][N:2]1[CH2:3][C@H:4]2[N:10]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[C@H:8]([CH2:7][CH:6]([C:18]([O:20][CH3:21])=[O:19])[CH2:5]2)[CH2:9]1参加物
4
実験手順
To a solution of (1R,5S)-9-tert-butyl 7-methyl 3-methyl-3,9-diazabicyclo[3.3.1]non-6-ene-7,9-dicarboxylate (4.69 g, 15.8 mmol) in methanol (50 mL) was added palladium on carbon (10%, 1.684 g, 1.583 mmol) and the resulting mixture was subjected to hydrogenation under 40 psi for three days. After filtration through CELITE® under nitrogen the filtrate was concentrated to give the title compound. LC/MS: (M+1)+: 299.1.
後処理
- filtrationAfter filtration through CELITE® under nitrogen the filtrate