Trifluoroacetic acid → 2-(4-Methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]dec-3-en-1-one
反応式
[CH3:1][C:2]1[C:6](=[O:7])[O:5][CH2:4][C:3]=1[N:8]1[CH:12]=[CH:11][C:10]2([CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)[C:9]1=[O:25].C(O)(C(F)(F)F)=O>>[CH3:1][C:2]1[C:6](=[O:7])[O:5][CH2:4][C:3]=1[N:8]1[CH:12]=[CH:11][C:10]2([CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[C:9]1=[O:25]参加物
3
実験手順
The title compound was prepared from tert-Butyl 2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-1-oxo-2,8-diazaspiro[4.5]dec-3-ene-8-carboxylate using TFA in an analogous fashion to that described for making 1-19, Step B. LC/MS: [(M+1)]+=249.
出典と根拠
- ORDレコード
- ord-f3e3e2ca2ded4b0e9e74eb773bc6ad7c
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08952166B2
反応ノート
読み込み中…