Diisopropyl Ether → HCID 86706788、化合物

HRID 1848770ノート

反応式

HRID 1848770 の反応式
[OH:1][C:2]1[CH:14]=[CH:13][C:5]2[C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:7][O:8][C:4]=2[CH:3]=1.[NH2:15][C@@H:16]([CH3:31])[C:17]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[OH:18].C(OC(C)C)(C)C>C(OCC)(=O)C>[NH2:15][C@@H:16]([CH3:31])[C:17]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[OH:18].[OH:1][C:2]1[CH:14]=[CH:13][C:5]2[C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:7][O:8][C:4]=2[CH:3]=1

参加物

5

反応物 3

HCID 7914Diisopropyl EtherHCID 681926(2S)-2-Amino-1,1-diphenylpropan-1-olHCID 21109152-(6-Hydroxy-1-benzofuran-3-yl)acetic acid

生成物 1

HCID 86706788HCID 86706788、化合物収率 98.6%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
60 °C

実験手順

(6-Hydroxy-1-benzofuran-3-yl)acetic acid (25.00 g) and (S)-2-amino-1,1-diphenylpropan-1-ol (29.57 g) were added to ethyl acetate (175 mL), and the mixture was dissolved by stirring at 60° C. After allowing to cool to room temperature, isopropyl ether (200 mL) was added, and the mixture was stirred for 1 hr. The solid was collected by filtration, and washed with a mixed solvent (1:1, 100 mL) of ethyl acetate-isopropyl ether. The solid was dried under reduced pressure at 50° C. to give the title compound (53.81 g).

後処理

  1. dissolutionthe mixture was dissolved
  2. temperatureto cool to room temperature
  3. stirringthe mixture was stirred for 1 hr
  4. filtrationThe solid was collected by filtration
  5. washwashed with a mixed solvent (1:1, 100 mL) of ethyl acetate-isopropyl ether
  6. customThe solid was dried under reduced pressure at 50° C.

出典と根拠

ORDレコード
ord-36126c47527c46ce8872b037f179c158
出典データセット
uspto-grants-2015_02
特許番号
US08952185B2

反応ノート

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