Sodium borohydride → [2-(4-Chlorophenyl)thiazol-5-yl]methanol

HRID 1849974ノート

反応式

HRID 1849974 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([CH:13]=[O:14])=[CH:11][N:12]=2)=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]([CH2:13][OH:14])=[CH:11][N:12]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 450368222-(4-Chlorophenyl)-1,3-thiazole-5-carbaldehyde

生成物 1

HCID 59562416[2-(4-Chlorophenyl)thiazol-5-yl]methanol収率 98.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a suspension of 2-(4-chlorophenyl)thiazole-5-carbaldehyde (3.26 g, 14.6 mmol) in methanol (50 ml) is added the sodium borohydride (568 mg, 15 mmol) portionwise at room temperature. The reaction mixture is stirred at room temperature for 2 h. The reaction mixture is quenched with 50 ml of an aqueous saturated solution of ammonium chloride, extracted with dichloromethane (2×100 ml). The combined organic extracts are dried with magnesium sulphate, filtered and evaporated to dryness to give [2-(4-chlorophenyl)thiazol-5-yl]methanol (3.24 g).

後処理

  1. customThe reaction mixture is quenched with 50 ml of an aqueous saturated solution of ammonium chloride
  2. extractionextracted with dichloromethane (2×100 ml)
  3. dry with materialThe combined organic extracts are dried with magnesium sulphate
  4. filtrationfiltered
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-31e7fe97978645ac95802f4f75d84ec1
出典データセット
uspto-grants-2015_02
特許番号
US08956999B2

反応ノート

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