Thionyl Chloride → 5-Chloromethyl-2-(4-chlorophenyl)thiazole
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([CH2:13]O)=[CH:11][N:12]=2)=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>ClCCl>[Cl:17][CH2:13][C:10]1[S:9][C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)=[N:12][CH:11]=1参加物
4
実験手順
To a suspension of [2-(4-chlorophenyl)thiazol-5-yl]methanol (3.24 g, 14.3 mmol) in dichloromethane (40 ml) is added dropwise the thionyl chloride (1.3 ml, 18 mmol) at room temperature under nitrogen. The reaction mixture is stirred at room temperature for 4 hours. Silica gel is added to the crude reaction mixture, the solvent is evaporated under reduced pressure and the residue is purified by flash chromatography on silica gel to give 5-chloromethyl-2-(4-chlorophenyl)thiazole (3.24 g)
後処理
- additionSilica gel is added to the crude
- customreaction mixture
- customthe solvent is evaporated under reduced pressure
- customthe residue is purified by flash chromatography on silica gel
出典と根拠
- ORDレコード
- ord-0b240d2eaf9645ea991853f99463f79f
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08956999B2
反応ノート
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