7-(2,4-Dimethoxy-benzyl)-2-oxa-7-aza-spiro[3.5]nonane → 2-Oxa-7-azaspiro[3.5]nonane
反応式
COC1C=C(OC)C=CC=1C[N:6]1[CH2:14][CH2:13][C:9]2([CH2:12][O:11][CH2:10]2)[CH2:8][CH2:7]1>CO.[OH-].[OH-].[Pd+2]>[CH2:10]1[C:9]2([CH2:13][CH2:14][NH:6][CH2:7][CH2:8]2)[CH2:12][O:11]1参加物
4
実験手順
To a solution of 7-(2,4-Dimethoxy-benzyl)-2-oxa-7-aza-spiro[3.5]nonane (125) (300 mg, 1.1 mmol) in MeOH (10 mL) was added Pd(OH)2 (300 mg). The reaction solution was stirred at RT overnight under H2 atmosphere. LCMS showed that most of the staring material was consumed. The mixture was filtered and concentrated to give the product (126) (112 mg, 0.88 mmol, yield: 80%). ESI-MS (M+1): 128 calc. for C7H13NO 127.
後処理
- customwas consumed
- filtrationThe mixture was filtered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-605acc0ffe414be1973040b23ca43039
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08957073B2
反応ノート
読み込み中…