(R)-4-chloro-6-((1-methylpiperidin-3-yl)oxy)pyrimidin-5-amine → (R)-4((1-methylpiperidin-3-yl)oxy)pyrimidin-5-amine
反応式
Cl[C:2]1[C:7]([NH2:8])=[C:6]([O:9][C@@H:10]2[CH2:15][CH2:14][CH2:13][N:12]([CH3:16])[CH2:11]2)[N:5]=[CH:4][N:3]=1>CO.[Pd]>[CH3:16][N:12]1[CH2:13][CH2:14][CH2:15][C@@H:10]([O:9][C:6]2[C:7]([NH2:8])=[CH:2][N:3]=[CH:4][N:5]=2)[CH2:11]1参加物
4
実験手順
(R)-4-chloro-6-((1-methylpiperidin-3-yl)oxy)pyrimidin-5-amine was dissolved in MeOH (15.0 mL) and Pd/C 10% (324.5 mg, 0.3049 mmol) was added and the reaction mixture stirred under a hydrogen atmosphere for 2 h. The reaction vessel was evacuated and flushed with nitrogen (3×), filtered through a celite pad washing with methanol followed by ethyl acetate. The combined filtrates were concentrated in vacuo to leave the title product 7a as a colourless oil (631 mg, 99%).
後処理
- customThe reaction vessel was evacuated
- customflushed with nitrogen (3×)
- filtrationfiltered through a celite pad
- washwashing with methanol
- concentrationThe combined filtrates were concentrated in vacuo
出典と根拠
- ORDレコード
- ord-5811122b801a46ee9ccb51820b1fdb65
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08957078B2
反応ノート
読み込み中…