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HRID 1850844作成日：2026年10月26日

1-(p-Chlorophenyl)cyclobutanecarboxylic acid → 2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine

https://huagongshe.com/reaction/1850844

反応式

関与物質

役割名称HCID仕込み量
反応物1-(p-Chlorophenyl)cyclobutanecarboxylic acidHCID 602761—
反応物2-(4-Methoxyphenyl)-2-methylpropan-1-amineHCID 3581364—
反応物1-(4-Fluorophenyl)cyclobutanecarboxylic acidHCID 16769017—
反応物2-({1-[1-(4-Fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamineHCID 58246324—
生成物2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethanamineHCID 58246302—

反応手順

2-({1-[1-(4-Chlorophenyl)cyclobutyl]-4,4-dimethyl-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine was prepared analogously to 2-({1-[1-(4-fluorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)ethanamine (cf. example 65) using 2-(4-methoxyphenyl)-2-methylpropan-1-amine and 1-(4-chlorophenyl)cyclobutanecarboxylic acid in place of 2-(4-methoxyphenyl)ethanamine and 1-(4-fluorophenyl)cyclobutanecarboxylic acid, respectively.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08957089B2
出典データセットuspto-grants-2015_02
ORD IDord-6e8e71afa12b4646a18c76613196a50f
出典メモuspto-grants-2015_02