Sodium Hydroxide → HCID 10374990、化合物

HRID 1851083ノート

反応式

HRID 1851083 の反応式
[OH-].[Na+].[O:3]=[C:4]1[C:9]([C:10]([O:12]CC)=[O:11])=[CH:8][NH:7][N:6]2[CH:15]=[CH:16][CH:17]=[C:5]12>C(O)C>[O:3]=[C:4]1[C:9]([C:10]([OH:12])=[O:11])=[CH:8][NH:7][N:6]2[CH:15]=[CH:16][CH:17]=[C:5]12

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10104421ETHYL 4-OXO-1,4-DIHYDROPYRROLO[1,2-B]PYRIDAZINE-3-CARBOXYLATE

生成物 1

HCID 10374990HCID 10374990、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
100 °C

実験手順

2 M sodium hydroxide aqueous solution was added to a suspension of ethyl 4-oxo-1,4-dihydropyrrolo[1,2,b]pyridazin-3-carboxylate in ethanol (165 mL) and stirred overnight at 100° C. The resulting reaction mixture was cooled to room temperature, distilled under reduced pressure, and concentrated. Then, concentrated hydrochloric acid was added until pH decreased to 2. Thereafter, the solid was filtered, washed with water and dried in vacuum. The target compound obtained was subjected to the next step without further purification.

後処理

  1. customThe resulting reaction mixture
  2. temperaturewas cooled to room temperature
  3. distillationdistilled under reduced pressure
  4. concentrationconcentrated
  5. additionThen, concentrated hydrochloric acid was added until pH
  6. filtrationThereafter, the solid was filtered
  7. washwashed with water
  8. customdried in vacuum
  9. customThe target compound obtained
  10. customwas subjected to the next step without further purification

出典と根拠

ORDレコード
ord-cfe3ec87e500410f9d2862fb23efa607
出典データセット
uspto-grants-2015_02
特許番号
US08957102B2

反応ノート

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