Lawesson's reagent → 7-nitro-1H-indole-2-carbothioamide
反応式
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][C:10]([C:13]([NH2:15])=O)=[CH:9]2)([O-:3])=[O:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:25])=CC=1>O1CCCC1>[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][C:10]([C:13](=[S:25])[NH2:15])=[CH:9]2)([O-:3])=[O:2]参加物
4
反応条件
- 温度
- 50 °C
実験手順
A mixture of 7-nitro-1H-indole-2-carboxamide (2.50 g), Lawesson's reagent (5.42 g) and tetrahydrofuran (50 mL) was stirred at 50° C. overnight. The reaction mixture was concentrated, and the resulting crystals were filtrated, washed with toluene, and dried to give the title compound (2.08 g, yield 77%) as yellow crystals. melting point>237° C. (decomposition).
後処理
- concentrationThe reaction mixture was concentrated
- filtrationthe resulting crystals were filtrated
- washwashed with toluene
- customdried
出典と根拠
- ORDレコード
- ord-5e685f5067724c0088bef8be3ea2ff52
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08957070B2
反応ノート
読み込み中…