Lawesson's reagent → 6-chloro-7-[(2-thienylsulfonyl)amino]-1H-indole-2-carbothioamide

HRID 1851404ノート

反応式

HRID 1851404 の反応式
[Cl:1][C:2]1[C:10]([NH:11][S:12]([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)(=[O:14])=[O:13])=[C:9]2[C:5]([CH:6]=[C:7]([C:20]([NH2:22])=O)[NH:8]2)=[CH:4][CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:32])=CC=1>O1CCCC1>[Cl:1][C:2]1[C:10]([NH:11][S:12]([C:15]2[S:16][CH:17]=[CH:18][CH:19]=2)(=[O:14])=[O:13])=[C:9]2[C:5]([CH:6]=[C:7]([C:20](=[S:32])[NH2:22])[NH:8]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 87949Lawesson's reagentHCID 574760286-chloro-7-[(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide

生成物 1

HCID 574760296-chloro-7-[(2-thienylsulfonyl)amino]-1H-indole-2-carbothioamide収率 91%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
60 °C

実験手順

A mixture of 6-chloro-7-[(2-thienylsulfonyl)amino]-1H-indole-2-carboxamide (0.80 g), Lawesson's reagent (0.90 g) and tetrahydrofuran (15 mL) was stirred at 60° C. for 3 hr. The reaction mixture was concentrated, toluene was added, and the resulting crystals were filtrated, washed with toluene, and dried to give the title compound (0.75 g, yield 91%) as yellow crystals. melting point 228-230° C. (decomposition).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additiontoluene was added
  3. filtrationthe resulting crystals were filtrated
  4. washwashed with toluene
  5. customdried

出典と根拠

ORDレコード
ord-2ac63044d6fe430091979aa8d7680b3e
出典データセット
uspto-grants-2015_02
特許番号
US08957070B2

反応ノート

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