HCID 57901756、化合物 → HCID 57901650、化合物

HRID 1851456ノート

反応式

HRID 1851456 の反応式
[OH:1][CH2:2][C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[NH:12][S:13]([C:16]1[S:17][CH:18]=[CH:19][CH:20]=1)(=[O:15])=[O:14]>[O-2].[O-2].[Mn+4].O1CCCC1>[CH:2]([C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[NH:12][S:13]([C:16]1[S:17][CH:18]=[CH:19][CH:20]=1)(=[O:14])=[O:15])=[O:1]

参加物

4

反応物 1

HCID 57901756HCID 57901756、化合物

生成物 1

HCID 57901650HCID 57901650、化合物収率 9.3%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of N-[2-(hydroxymethyl)-1H-indol-7-yl]thiophene-2-sulfonamide (1.30 g), activated manganese dioxide (8.0 g) and tetrahydrofuran (30 mL) was stirred at room temperature for 5 hr. The reaction mixture was filtrated, and the filtrate was concentrated. The residue was subjected to silica gel column chromatography, and the title compound (0.12 g, yield 9%) was obtained as yellow crystals from a fraction eluted with tetrahydrofuran-hexane (2:1, volume ratio). melting point>226° C. (decomposition).

後処理

  1. filtrationThe reaction mixture was filtrated
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-f79df25f89af4b9981d28e12c5604138
出典データセット
uspto-grants-2015_02
特許番号
US08957070B2

反応ノート

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