Dimethylamine → HCID 178487766、化合物

反応式

Cl[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[C:4](=[CH:5][C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=1.C1COCC1.[CH3:20][NH:21][CH3:22]>>[CH3:20][N:21]([CH3:22])[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[C:4](=[CH:5][C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=1

参加物

反応物 3

HCID 674Dimethylamine

HCID 8028Tetrahydrofuran

HCID 178487751HCID 178487751、化合物

生成物 1

HCID 178487766HCID 178487766、化合物

反応条件

温度: 100 °C

実験手順

2-chloro-7-methoxyquinazolin-4-ol (288 mg, 1.368 mmol) was dissolved in Dimethylamine 2 M in THF (2 ml, 4.00 mmol) and heated to 100° C. for 1 h in a sealed tube. The reaction was cooled and the volatiles were removed under vacuum. The crude solid was collected and washed with water, filtered and dried to give 2-(dimethylamino)-7-methoxyquinazolin-4-ol which was carried to the next step without further purification. MS: MS m/z 220.1 (M++1).