m-Chloroperbenzoic acid → 4-Methylisoquinoline 2-oxide

HRID 1852210ノート

反応式

HRID 1852210 の反応式
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[N:4][CH:3]=1.C1C=C(Cl)C=C(C(OO)=[O:20])C=1>C(Cl)Cl>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[N+:4]([O-:20])[CH:3]=1

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 640939Isoquinoline, 4-methyl-

生成物 1

HCID 229588294-Methylisoquinoline 2-oxide収率 97.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 4-methylisoquinoline (0.6 g, 4.19 mmol) in DCM (20 ml) was added m-CPBA (2.169 g, 12.57 mmol) at room temperature. The reaction mass was stirred at the same temperature for 18 h. The reaction mass was diluted with DCM and extracted with water. The combined organic layer was dried over anhydrous Na2SO4 and evaporated under reduced pressure to get desired compound (0.65 g, 88%) as a semi solid. The crude compound was taken further without purification.

後処理

  1. extractionextracted with water
  2. dry with materialThe combined organic layer was dried over anhydrous Na2SO4
  3. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-68095ebeb1fb41e9beb633b3a4ec0292
出典データセット
uspto-grants-2015_02
特許番号
US08957203B2

反応ノート

読み込み中…