m-Chloroperbenzoic acid → Isoquinoline, 4-cyclopropyl-, 2-oxide
反応式
[CH:1]1([C:4]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH:7]=[N:6][CH:5]=2)[CH2:3][CH2:2]1.C1C=C(Cl)C=C(C(OO)=[O:22])C=1>C(Cl)Cl>[CH:1]1([C:4]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH:7]=[N+:6]([O-:22])[CH:5]=2)[CH2:3][CH2:2]1参加物
4
実験手順
To a solution of 4-cyclopropylisoquinoline (0.4 g, 2.364 mmol) in DCM (10 ml) was added m-CPBA (1.224 g, 7.09 mmol) at room temperature. The reaction mass was stirred at the same temperature for 18 h. The reaction mass was diluted with DCM and washed with water and aqueous sodium bicarbonate solution. The combined organic layer was dried over anhydrous Na2SO4 and evaporated under reduced pressure to get desired compound (0.35 g, 80%) as solid. The crude compound was taken further without purification.
後処理
- washwashed with water and aqueous sodium bicarbonate solution
- dry with materialThe combined organic layer was dried over anhydrous Na2SO4
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-d49eff751acf483f92974daf031eb141
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08957203B2
反応ノート
読み込み中…