Hydrogen Bromide → 5-Bromo-3-Methylpentanoic Acid

A solution of β-methyl-δ-valerolactone (3.0 g) in anhydrous dichloromethane (30 ml), cooled to 0-5° C., was saturated with hydrogen bromide gas and the mixture was stirred for three days at room temperature. The mixture was diluted with dichloromethane (100 ml) and the resulting solution was washed with 10-% NaCl (3×30 ml). Next the solution was dried with anhydrous MgSO4 and the solvent was distilled under reduced pressure, Yield: 4.6 g. NMR 100% pure product.

1. washthe resulting solution was washed with 10-% NaCl (3×30 ml)
2. dry with materialNext the solution was dried with anhydrous MgSO4
3. distillationthe solvent was distilled under reduced pressure, Yield: 4.6 g

ORDレコード

ord-c2030f52d23f4c71af2395ebf423fc47

出典データセット

uspto-grants-2015_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08962566B2