Heptane → HCID 54684579、化合物

HRID 1852413ノート

反応式

HRID 1852413 の反応式
C[N:2]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:3]([C:5]1[C:6](=[O:17])[N:7]([CH3:16])[C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:4].[F:24]C1C=CC(N)=CC=1.CCCCCCC>C1(C)C=CC=CC=1>[F:24][C:21]1[CH:22]=[CH:23][C:18]([NH:2][C:3]([C:5]2[C:6](=[O:17])[N:7]([CH3:16])[C:8]3[C:13]([C:14]=2[OH:15])=[CH:12][CH:11]=[CH:10][CH:9]=3)=[O:4])=[CH:19][CH:20]=1

参加物

5

反応物 3

HCID 8900HeptaneHCID 97314-FluoroanilineHCID 54676478Roquinimex

生成物 1

HCID 54684579HCID 54684579、化合物収率 79%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of N-methyl-N-phenyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide (15 mg, 0.050 mmol) and 4-fluoro-aniline (0.100 mmol) in toluene (0.5 mL) was stirred at 100° C. for 1 h. Heptane (1.5 mL) was added and the solution was allowed to cool to room temperature. The crystallized product was separated from the solution and washed with heptane to give the title compound (12 mg, 79%).

後処理

  1. customThe crystallized product was separated from the solution
  2. washwashed with heptane

出典と根拠

ORDレコード
ord-be9d88eac4554872b56850416c322980
出典データセット
uspto-grants-2015_02
特許番号
US08962598B2

反応ノート

読み込み中…