Nitrogen → 6-Oxospiro[2.5]octane-5-carbonitrile

HRID 1852473ノート

反応式

HRID 1852473 の反応式
[O:1]=[C:2]1[CH2:9][CH2:8][C:5]2([CH2:7][CH2:6]2)[CH:4]=[C:3]1[C:10]#[N:11].N#N>CO.[Pd]>[O:1]=[C:2]1[CH2:9][CH2:8][C:5]2([CH2:6][CH2:7]2)[CH2:4][CH:3]1[C:10]#[N:11]

参加物

5

反応物 2

HCID 947NitrogenHCID 867310096-Oxospiro[2.5]oct-4-ene-5-carbonitrile

生成物 1

HCID 867310106-Oxospiro[2.5]octane-5-carbonitrile

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

6-Oxospiro[2.5]oct-4-ene-5-carbonitrile (0.16 g, 1.1 mmol) was dissolved in MeOH (11 mL) and combined with 10% palladium on activated carbon (0.12 g, 0.11 mmol). The resulting mixture was subjected to alternating vacuum and H2 gas (4×). The mixture was then stirred under an atmosphere of H2 (50 psi) for 16 hours. The mixture was then subjected to alternating vacuum and N2 gas (4×). The mixture was filtered through celite and rinsed with MeOH. The filtrate was concentrated in vacuo to afford the title compound. The material was used without further purification.

後処理

  1. filtrationThe mixture was filtered through celite
  2. washrinsed with MeOH
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-0c79da19d7264276beaac0fcf37660f1
出典データセット
uspto-grants-2015_02
特許番号
US08962608B2

反応ノート

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