Lithium borohydride → 6-Hydroxyspiro[2.5]octane-5-carbonitrile

HRID 1852474ノート

反応式

HRID 1852474 の反応式
[O:1]=[C:2]1[CH2:9][CH2:8][C:5]2([CH2:7][CH2:6]2)[CH2:4][CH:3]1[C:10]#[N:11].[BH4-].[Li+]>C1COCC1.O>[OH:1][CH:2]1[CH2:9][CH2:8][C:5]2([CH2:6][CH2:7]2)[CH2:4][CH:3]1[C:10]#[N:11]

参加物

5

反応物 2

HCID 4148881Lithium borohydrideHCID 867310106-Oxospiro[2.5]octane-5-carbonitrile

生成物 1

HCID 867310116-Hydroxyspiro[2.5]octane-5-carbonitrile

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 6-oxospiro[2.5]octane-5-carbonitrile (130 mg, 0.87 mmol) in THF (4.3 mL) was stirred at ambient temperature and lithium borohydride (76 mg, 3.5 mmol) was added. The resulting mixture was stirred at ambient temperature for 16 hours. The mixture was diluted with water and extracted with EtOAc (2×). The combined organic extracts were washed with water, brine, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo to afford the title compound. The material was used without further purification.

後処理

  1. extractionextracted with EtOAc (2×)
  2. washThe combined organic extracts were washed with water, brine
  3. dry with materialdried over anhydrous Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-713ed157942f44dbadb358a83569b8a8
出典データセット
uspto-grants-2015_02
特許番号
US08962608B2

反応ノート

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