Dichloromethane → 1-(Benzo[b]thiophen-3-yl)-3-chloropropan-2-one

HRID 1852523ノート

反応式

HRID 1852523 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1.[Al+3].[Cl-].[Cl-].[Cl-].ClC[CH2:16][C:17](Cl)=[O:18].Cl[CH2:21][Cl:22]>>[Cl:22][CH2:21][C:17](=[O:18])[CH2:16][C:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[S:1][CH:2]=1

参加物

5

反応物 4

HCID 6344DichloromethaneHCID 7221Benzo(B)ThiopheneHCID 693643-Chloropropionyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 161001791-(Benzo[b]thiophen-3-yl)-3-chloropropan-2-one収率 85.3%

実験手順

To the solution of benzothiophene (0.05 mol) dissolved in dichloromethane (30 mL), AlCl3 (0.10 mol) is added batch by batch and 3-chloropropionyl chloride (0.055 mol) is added dropwise, while the internal temperature is maintained below 5° C. Following procedures described in General Method One—Method A, 3-chloro-1-(benzothiophen-3- yl)-acetone is obtained as a white solid (9.6 g). The yield is 85.3%. MS(m/z): 225.0 [M+1]+.

後処理

  1. additionis added dropwise, while the internal temperature
  2. temperatureis maintained below 5° C

出典と根拠

ORDレコード
ord-c1da22cab2d345e880e6133689856ae5
出典データセット
uspto-grants-2015_02
特許番号
US08962621B2

反応ノート

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