Methyl 2-acetamidoacrylate → Methyl 7-chloroisoquinoline-3-carboxylate
反応式
Br[C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH:4]=O.C([NH:14][C:15](=[CH2:20])[C:16]([O:18][CH3:19])=[O:17])(=O)C>>[Cl:10][C:7]1[CH:6]=[C:3]2[C:2]([CH:20]=[C:15]([C:16]([O:18][CH3:19])=[O:17])[N:14]=[CH:4]2)=[CH:9][CH:8]=1参加物
3
実験手順
methyl 7-chloro-isoquinoline-3-carboxylate was prepared using the procedure described in example 12A: 2-bromo-5-chlorobenzaldehyde was reacted with methyl 2-acetamidoacrylate at 110° C. for 24 hours to yield methyl 7-chloro-isoquinoline-3-carboxylate (25%) as brown solid.
後処理
- custommethyl 7-chloro-isoquinoline-3-carboxylate was prepared
出典と根拠
- ORDレコード
- ord-ffda6479c38f4da3a4e42b85c693c17d
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08962627B2
反応ノート
読み込み中…