Thionyl Chloride → HCID 86648157、化合物

反応式

[Cl:1][C:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][C:4]([CH2:12][C:13]([OH:15])=O)([CH2:5]3)[CH2:3]1)[CH2:9]2.S(Cl)([Cl:18])=O>>[Cl:1][C:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][C:4]([CH2:12][C:13]([Cl:18])=[O:15])([CH2:5]3)[CH2:3]1)[CH2:9]2

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 2802826HCID 2802826、化合物

生成物 1

HCID 86648157HCID 86648157、化合物収率 98.3%

実験手順

(3-Chloroadamantan-1-yl)acetic acid (607.5 mg, 2.66 mmol) was dissolved in thionyl chloride (5 mL, 68.5 mmol). The reaction mixture was heated at reflux for 5 hours. The reaction mixture was cooled and then concentrated in vacuo to provide the title compound as a white solid (646.4 mg, 98%) that was used without additional purification.

後処理

temperatureThe reaction mixture was heated
temperatureat reflux for 5 hours
temperatureThe reaction mixture was cooled
concentrationconcentrated in vacuo

出典と根拠

ORDレコード: ord-7e65cb36fdbc4bb1862a796ecf2cff76
出典データセット: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08962639B2

反応ノート

読み込み中…

参加物