Ethyl 2-(bicyclo[3.3.1]nonan-9-yl)acetate → 2-(Bicyclo[3.3.1]nonan-9-yl)acetic acid

HRID 1853432ノート

反応式

HRID 1853432 の反応式
[CH:1]12[CH:9]([CH2:10][C:11]([O:13]CC)=[O:12])[CH:5]([CH2:6][CH2:7][CH2:8]1)[CH2:4][CH2:3][CH2:2]2>CO.[OH-].[Na+]>[CH:5]12[CH:9]([CH2:10][C:11]([OH:13])=[O:12])[CH:1]([CH2:2][CH2:3][CH2:4]1)[CH2:8][CH2:7][CH2:6]2

参加物

4

反応物 1

HCID 68773303Ethyl 2-(bicyclo[3.3.1]nonan-9-yl)acetate

生成物 1

HCID 229236192-(Bicyclo[3.3.1]nonan-9-yl)acetic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

To a solution of Example 56B (8.5 g 40.4 mmol) in methanol (100 mL), aqueous NaOH (50%, 25 mL) was added. The reaction was stirred at room temperature for 24 hours. Methanol was evaporated and the mixture was extracted with ether and then acidified with 6N HCl to pH 2. The mixture was extracted with ether (2×50 mL), the organic layer was dried with magnesium sulfate, filtered, and concentrated to afford the title compound.

後処理

  1. customMethanol was evaporated
  2. extractionthe mixture was extracted with ether
  3. extractionThe mixture was extracted with ether (2×50 mL)
  4. dry with materialthe organic layer was dried with magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-72d914873ea8410ea1a4165b6d632424
出典データセット
uspto-grants-2015_02
特許番号
US08962639B2

反応ノート

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