2-Oxazolidinone → 1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-1H-benzoimidazole-2-carboxylic acid [4-(2-oxo-oxazolidin-3-yl)-phenyl]-amide

HRID 18536

反応式

HRID 18536 の反応式
[O:1]1[CH2:5][CH2:4][NH:3][C:2]1=[O:6].Br[CH2:8][C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][N:13]=1)=[O:10].BrC[C:21]1[CH:25]=[C:24]([C:26]2SC(Cl)=[CH:29][CH:30]=2)O[N:22]=1>>[O:6]=[C:2]1[N:3]([C:26]2[CH:30]=[CH:29][C:21]([NH:22][C:5]([C:4]3[N:22]([CH2:8][C:9](=[O:10])[NH:11][C:12]4[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][N:13]=4)[C:21]4[CH:25]=[CH:24][CH:26]=[CH:30][C:29]=4[N:3]=3)=[O:1])=[CH:25][CH:24]=2)[CH2:4][CH2:5][O:1]1

参加物

4

反応物 3

HCID 739492-OxazolidinoneHCID 34211102-Bromo-N-(5-chloro-2-pyridinyl)acetamideHCID 111501463-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole

生成物 1

HCID 670136111-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-1H-benzoimidazole-2-carboxylic acid [4-(2-oxo-oxazolidin-3-yl)-phenyl]-amide

実験手順

The title compound was prepared analogously to example 41 with the difference that Oxazolidin-2-one and 2-Bromo-N-(5-chloro-pyridin-2-yl)-acetamide was used instead of 1H-Pyrimidine-2,4-dione (step (i)) and 3-Bromomethyl-5-(5-chloro-thiophen-2-yl)-isoxazole (step (iv)).

出典と根拠

ORDレコード
ord-ba393921cf4b455095b108bbac5cac74
出典データセット
uspto-grants-2010_06
特許番号
US07741341B2

関連ノート

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