Pinacol → 3-Chloropropenyl-1-boronic acid pinacol ester
反応式
[Cl:1][CH2:2]/[CH:3]=[CH:4]/[B:5]([OH:7])[OH:6].O[C:9]([C:12](O)([CH3:14])[CH3:13])([CH3:11])[CH3:10].S([O-])([O-])(=O)=O.[Mg+2]>C(Cl)Cl>[Cl:1][CH2:2]/[CH:3]=[CH:4]/[B:5]1[O:7][C:12]([CH3:14])([CH3:13])[C:9]([CH3:11])([CH3:10])[O:6]1参加物
5
実験手順
A solution of (E)-3-chloroprop-1-enylboronic acid (5 g, 41 mmol), pinacol (4.9 g, 41 mmol), and magnesium sulfate (15 g, 120 mmol) in methylene chloride (100 mL) was stirred at room temperature for 18 h. The reaction mixture was filtered through silica gel and the filter cake was washed with methylene chloride. The filtrate was concentrated to afford the desired product (4.8 g, 60%) as a colorless oil: ESI MS m/z 203 [C9H16BClO2+H]+.
後処理
- filtrationThe reaction mixture was filtered through silica gel
- washthe filter cake was washed with methylene chloride
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-b6f8ebc4cc6a4d118f83508cf7823cbd
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08962648B2
反応ノート
読み込み中…