Thionyl Chloride → HCID 86689574、化合物
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.S(Cl)([Cl:19])=O>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]([C:14]([Cl:19])=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
To a solution of 5-(4-methoxyphenyl)thiophene-2-carboxylic acid (0.60 g, 2.5 mmol) in toluene (4 mL) was added thionylchloride (560 mL, 7.7 mmol) and the reaction mixture was heated at 100° C. for 18 h. The reaction mixture was cooled to room temperature and concentrated to afford the desire product (642 mg, crude): ESI MS m/z 253 [C12H9ClO2S+H]+.
後処理
- temperatureThe reaction mixture was cooled to room temperature
- concentrationconcentrated
- customto afford the desire product (642 mg, crude)
出典と根拠
- ORDレコード
- ord-677ca72c472642169f6dc1e6cb0b26a0
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08962648B2
反応ノート
読み込み中…