Sodium Hydroxide → 5-Amino-1-phenyl-1H-pyrazole-3-carboxylic acid
反応式
[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]([O:15]CC)=[O:14])[CH:3]=1.[OH-].[Na+]>CCO>[NH2:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]([OH:15])=[O:14])[CH:3]=1参加物
4
実験手順
2 g (8.65 mmol) of ethyl 5-amino-1-phenyl-1H-pyrazole-3-carboxylate are dissolved in 20 ml EtOH and 20 ml of 1M NaOH solution are added. The mixture is stirred overnight, the solvent removed in vacuo and the crude product subject to HPLC chromatography: Yield: 65%
後処理
- customthe solvent removed in vacuo
出典と根拠
- ORDレコード
- ord-b72cc373c3ff4338887adf24861b0448
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08962671B2
反応ノート
読み込み中…