Sodium Hydroxide → HCID 70665037、化合物
反応式
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([NH:11][CH2:12][C:13](=[O:18])[C:14]([CH3:17])([CH3:16])[CH3:15])[N:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[N:7]=1)=[O:5])C.[OH-].[Na+]>C(O)C>[CH3:15][C:14]([CH3:17])([CH3:16])[C:13](=[O:18])[CH2:12][NH:11][C:9]1[N:8]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:10]=1参加物
4
実験手順
2 g (6.07 mmol) of 5-(3,3-Dimethyl-2-oxo-butylamino)-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester are dissolved in 15 ml ethanol, 12.1 ml (12.1 mmol, 2 eq) 1N NaOH are added and the resulting mixture is stirred overnight at RT. After evaporation of the solvent the residue is taken up in a mixture of 10 ml CH2Cl2 and 10 ml 0.1N HCl, the organic phase is separated, dried over Na2SO4 and the solvent removed in vacuo to obtain 5-(3,3-Dimethyl-2-oxo-butylamino)-1-phenyl-1H-pyrazole-3-carboxylic acid in a yield of 82% (1.5 g)