Lithium Hydroxide → Quinaldic Acid

HRID 1854804ノート

反応式

HRID 1854804 の反応式
[OH-].[Li+].[N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[C:13]([O:15]C)=[O:14]>O.CO>[N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[C:13]([OH:15])=[O:14]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 421738methyl quinoline-2-carboxylate

生成物 1

HCID 7124Quinaldic Acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a stirred solution of lithium hydroxide (20.0 mg, 0.84 mmol) in water (1 mL), methyl quinoline-2-carboxylate (20.0 mg, 0.11 mmol) in methanol (3 mL) was added. The solution was left to stir at room temperature for 2 h. The solution was then concentrated in vacuo. The yellow solid residue was dissolved in water and made acidic with concentrated hydrochloric acid. The organic material was extracted with ethyl acetate. The organic layers were dried with anhydrous sodium sulphate, filtered, and concentrated in vacuo to yield quinoline-2-carboxylic acid as a white solid.

後処理

  1. waitThe solution was left
  2. concentrationThe solution was then concentrated in vacuo
  3. dissolutionThe yellow solid residue was dissolved in water
  4. extractionThe organic material was extracted with ethyl acetate
  5. dry with materialThe organic layers were dried with anhydrous sodium sulphate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-3eb7a72d34414a93be14acdf8931ee1f
出典データセット
uspto-grants-2015_02
特許番号
US08962830B2

反応ノート

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