tert-Butoxy bis(dimethylamino)methane → 1-Dimethylamino-2-methyl-4-phenyl-pent-1-en-3-one

HRID 1855331ノート

反応式

HRID 1855331 の反応式
[C:1]1([CH:7]([C:9](=[O:12])[CH2:10][CH3:11])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O[CH:18]([N:22]([CH3:24])[CH3:23])N(C)C)(C)(C)C>>[CH3:24][N:22]([CH3:23])[CH:18]=[C:10]([CH3:11])[C:9](=[O:12])[CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:8]

参加物

3

反応物 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 41445242-Phenylpentan-3-one

生成物 1

HCID 686313161-Dimethylamino-2-methyl-4-phenyl-pent-1-en-3-one収率 117.6%

実験手順

A mixture of 2-phenyl-3-pentanone (106 mg, 0.54 mmol) and of tert.-butoxy-bis(dimethylamino)methane (146 mg, 0.75 mmol, 90%) was stirred at 110° C. for 16 h. The reaction was evaporated to dryness, treated twice with toluene and the solvent was evaporated under reduced pressure to give the crude title compound (138 mg, 97%) as a dark brown solid which was used directly in the next step without further purification.

後処理

  1. customThe reaction was evaporated to dryness
  2. additiontreated twice with toluene
  3. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-14c388b9ab404673a2163916c26483b8
出典データセット
uspto-grants-2015_02
特許番号
US08962834B2

反応ノート

読み込み中…