Isopropylamine → HCID 528635、化合物

反応式

[C:1]([NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8])(C)([CH3:3])[CH3:2].C(N)(C)C.C(N(CC)CC)C.C(Cl)(=O)C(C)(C)C>>[CH:1]([NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8])([CH3:3])[CH3:2]

参加物

反応物 4

HCID 6363Isopropylamine

HCID 8471Triethylamine

HCID 62493Pivaloyl chloride

HCID 299326N-tert-Butylpivalamide

生成物 1

HCID 528635HCID 528635、化合物収率 96%

実験手順

In a fashion similar to the preparation of LtBu,tBuH, treatment of isopropylamine (9.0 mL, 105 mmol) and triethylamine (14.9 mL, 105 mmol) with pivaloyl chloride (8.9 mL, 100 mmol) afforded LtBu,iPrH as white crystalline solid (13.75 g, 96%) upon sublimation at 55° C./0.05 Torr: mp 106-108° C.

出典と根拠

ORDレコード: ord-37851dbe5a584ace904b771f16bdcc4e
出典データセット: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08962876B2

反応ノート

読み込み中…