Hydrochloric Acid → 4-(4-trifluoromethoxyphenyl)benzylamine Hydrochloride

HRID 1855623ノート

反応式

HRID 1855623 の反応式
[F:1][C:2]([F:19])([F:18])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.FC(F)(F)OC1C=CC(B(O)O)=CC=1.[ClH:34]>C(O)C.[OH-].[OH-].[Pd+2]>[ClH:34].[F:1][C:2]([F:18])([F:19])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][NH2:17])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 27343864-(Trifluoromethoxy)phenylboronic acidHCID 214636134-[4-(Trifluoromethoxy)phenyl]benzonitrile

生成物 1

HCID 229284574-(4-trifluoromethoxyphenyl)benzylamine Hydrochloride

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

A solution of 4′-[(trifluoromethyl)oxy]-4-biphenylcarbonitrile (prepared from {4-[(trifluoromethyl)oxy]phenyl}boronic acid by a method analogous to that described for the 4′-trifluoromethyl analogue, Intermediate D6 of WO 02/30911) (66.6 g) in ethanol (2000 ml) and concentrated hydrochloric acid (100 ml) was hydrogenated over Pearlman's catalyst (10 g) at 25 psi until reduction was complete. The catalyst was removed by filtration through celite, then the solvent was removed in vacuo to obtain the desired product.

後処理

  1. customThe catalyst was removed by filtration through celite
  2. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-417e4b42768a406f93aa27a34c23b9a3
出典データセット
uspto-grants-2015_02
特許番号
US08962633B2

反応ノート

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