Trifluoroacetic acid → HCID 178510940、化合物

HRID 1855661

反応式

HRID 1855661 の反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C([N:27]1[CH:31]=[C:30]([CH2:32][CH2:33][CH2:34][NH2:35])[N:29]=[CH:28]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)Cl.CCOC(C)=O.O>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:27]1[CH:31]=[C:30]([CH2:32][CH2:33][CH2:34][NH2:35])[N:29]=[CH:28]1

参加物

6

反応物 2

HCID 6422Trifluoroacetic acidHCID 153458253-(1-trityl-1H-imidazol-4-yl)propan-1-amine

生成物 1

HCID 178510940HCID 178510940、化合物

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

2 ml of trifluoroacetic acid are added to 195 mg (0.53 mmol) of 3-(1-trityl-1H-imidazol-4-yl) propylamine dissolved in 8 ml of DCM and then immersed in an ice bath. After warming to room temperature, the reaction medium is stirred for 2 hours and the solvents are then evaporated off. The solid obtained is taken up in EtOAc and water. The aqueous phase is then concentrated and 110 mg of a white powder are obtained and used in the next step without further purification.

後処理

  1. customimmersed in an ice bath
  2. customthe solvents are then evaporated off
  3. customThe solid obtained
  4. concentrationThe aqueous phase is then concentrated

出典と根拠

ORDレコード
ord-e5f2840a2cd44d209ed34f98dc3dd253
出典データセット
uspto-grants-2015_02
特許番号
US08962846B2

関連ノート

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