2-(Diisopropylamino)ethyl chloride → alpha-(4-Biphenylyl)-alpha-[2-(diisopropylamino)ethyl]acetonitrile

HRID 1855964

反応式

HRID 1855964 の反応式
[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][C:4]([CH2:7][C:8]#[N:9])=[CH:3][CH:2]=1.Cl[CH2:17][CH2:18][N:19]([CH:23]([CH3:25])[CH3:24])[CH:20]([CH3:22])[CH3:21].[OH-].[Na+]>[Br-].C([N+](C)(C)C)C1C=CC=CC=1.C(Cl)Cl.O>[C:1]1([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:2]=[CH:3][C:4]([CH:7]([CH2:17][CH2:18][N:19]([CH:23]([CH3:25])[CH3:24])[CH:20]([CH3:22])[CH3:21])[C:8]#[N:9])=[CH:5][CH:6]=1

参加物

7

反応物 3

HCID 73122-(Diisopropylamino)ethyl chlorideHCID 14798Sodium HydroxideHCID 358564-Biphenylacetonitrile

生成物 1

HCID 14569341alpha-(4-Biphenylyl)-alpha-[2-(diisopropylamino)ethyl]acetonitrile

試薬・触媒・溶媒 3

HCID 21449Benzyltrimethylammonium bromide触媒HCID 962Water溶媒HCID 6344Dichloromethane溶媒2 回

実験手順

The mixture of 50 parts of α-(4-biphenylyl)acetonitrile, 45.8 parts of 2-chloro-N,N-diisopropylethylamine, 80 parts by volume of 50% sodium hydroxide, 250 parts by volume of methylene chloride and 1 part of benzyltrimethylammonium bromide is stirred at room temperature with slight cooling in an icy water bath for about 24 hours. The mixture is then poured into water and to this mixture additional quantity of methylene chloride is added. The organic layer is separated, washed with water, dried over anhydrous sodium sulfate and concentrated to afford α-(4-biphenylyl)-α-[2-(diisopropylamino)ethyl]acetonitrile, as a solid. This compound is identical to that of Example 1.

後処理

  1. temperaturewith slight cooling in an icy water bath for about 24 hours
  2. additionis added
  3. customThe organic layer is separated
  4. washwashed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-bee095f34501411d9fb398a67f21a714
出典データセット
uspto-grants-1980_08
特許番号
US04217306

関連ノート

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