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Sodium Hydroxide → alpha-(o-Fluorophenyl)-alpha-[2-(diisopropylamino)ethyl]-alpha-[2-(2-methyl-1-piperidinyl)ethyl]acetamide

HRID 1855968
ノート
印刷プレビュー

反応式

HRID 1855968 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([CH2:20][CH2:21][N:22]([CH:26]([CH3:28])[CH3:27])[CH:23]([CH3:25])[CH3:24])([CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[CH3:19])[C:9]#[N:10].[OH-:29].[Na+]>S(=O)(=O)(O)O.O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([CH2:20][CH2:21][N:22]([CH:23]([CH3:25])[CH3:24])[CH:26]([CH3:28])[CH3:27])([CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH:14]1[CH3:19])[C:9]([NH2:10])=[O:29]
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 12612248alpha-(o-Fluorophenyl)-alpha-[2-(diisopropylamino)ethyl]-alpha-[2-(2-methyl-1-piperidinyl)ethyl]acetonitrile

生成物 1

HCID 12612308alpha-(o-Fluorophenyl)-alpha-[2-(diisopropylamino)ethyl]-alpha-[2-(2-methyl-1-piperidinyl)ethyl]acetamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1118Sulfuric Acid溶媒

反応条件

温度
0 °C

実験手順

7 Parts of the preceding acetonitrile is dissolved in a solution of 67 parts by volume of concentrated sulfuric acid and 3 parts by volume of water. The resulting solution is heated on a steam bath for about 2 hours and then cooled to about 0° C. and made alkaline by the addition of diluted sodium hydroxide. The alkaline solution is extracted with ether, the ether extract dried over calcium sulfate, stripped of solvent and the residue crystallized from pentane to afford α-(o-fluorophenyl)-α-[2-(diisopropylamino)ethyl]-α-[2-(2-methyl-1-piperidinyl)ethyl]acetamide, melting at about 90°-91° C. This compound has the following structural formula ##STR30##

後処理

  1. temperatureThe resulting solution is heated on a steam bath for about 2 hours
  2. extractionThe alkaline solution is extracted with ether
  3. extractionthe ether extract
  4. dry with materialdried over calcium sulfate
  5. customthe residue crystallized from pentane

出典と根拠

ORDレコード
ord-ec22c3142b5143fbbd762507474f7ec1
出典データセット
uspto-grants-1980_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04217306

反応ノート

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このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート