5-Tert-butyl-m-xylene → 4-tert-butyl-2,6-dimethylbenzenesulfonyl chloride

反応式

[Cl:1][S:2]([OH:5])(=O)=[O:3].[CH3:6][C:7]1[CH:8]=[C:9]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:10]=[C:11]([CH3:13])[CH:12]=1>>[C:14]([C:9]1[CH:8]=[C:7]([CH3:6])[C:12]([S:2]([Cl:1])(=[O:5])=[O:3])=[C:11]([CH3:13])[CH:10]=1)([CH3:17])([CH3:16])[CH3:15]

参加物

反応物 2

HCID 73785-Tert-butyl-m-xylene

HCID 24638Chlorosulfonic acid

生成物 1

HCID 38685064-tert-butyl-2,6-dimethylbenzenesulfonyl chloride

反応条件

温度: 0 °C

実験手順

85 ml Chlorosulphonic acid (1.3 mole) was added to a mixture of 81 g (0.5 mole) 3,5 -dimethyl-tert.-butylbenzene at 0± 2° C. The reaction mixture was stirred at 0° C. for 1.5 hours, poured on ice and the layers were separated. The organic layer was washed with water, sodium bicarbonate, and water and was then dried with sodium sulphate. The solvent was removed in vacuum giving pale-yellow crystals of the title compound, m.p. 65° C.

後処理

additionpoured on ice
customthe layers were separated
washThe organic layer was washed with water, sodium bicarbonate, and water
dry with materialwas then dried with sodium sulphate
customThe solvent was removed in vacuum

出典と根拠

ORDレコード: ord-d05a79bf95d44af2b0711589058f59fa
出典データセット: uspto-grants-1980_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04218476

反応ノート

読み込み中…

参加物